| |
|
Synthetic Organic Chemistry
Organic synthesis lies at the heart of the chemistry. Our
research interests focus primarily in the area of organic
synthesis wherein we synthesize organic molecules bearing
interesting function including biological activity (natural
products, drugs, drug-like compounds etc.) or materials with
useful properties. We focus on solving problems that demand
mastery of the fundamentals of the subject to access complex
organic molecules, originating from the nature or derived from
rational design.
Our research interests include:
Total
Synthesis.
We
focus on the complete chemical synthesis
of organic molecules from simple, commercially available or
natural precursors. We explore synthetic strategies and employ judicious selection of organic
transformations to construct bioactive natural products of
complex molecular architechture.
Selected publications:
New Methodologies in Organic Synthesis.
We are also interested in to develop
tools to perform
efficient synthetic transformations in the creation of novel
molecular architectures. This includes the discovery and
development of new transformations by developing new reagents or
catalysts. The outcomes of such researches are directly
connected with our interests in the total synthesis of natural
products and
medicinal chemistry.
Selected publications:
Bio-organic Chemistry
This
research area is directed at the “lead” optimization and
synthesis of structural analogues of bioactive structural
motifs. The optimization of bioactivities is achieved through
particular modifications in the molecular structure of “lead”
compound.
Selected publications:
|
|
Funded Research Projects
|
SN
|
Title of the Project, Funds Amount and Funding
Agency
|
Role
|
Duration
|
Status
|
|
1
|
The first total synthesis of
Icmt inhibitors prenylated
b-hydroxy-chalcones
and spermatinamine, a new approach to anticancer
drug discovery, 89,400.00 SAR, Funded by Fast
Track, KFUPM, Project # FT090014
|
P.I
|
Sep. 2009 -
March 2011
|
completed in March 2011
|
|
2
|
The discovery of new generation potential
antipsychotic agents, 925,000.00 SAR,
Funded by KACST, Project # AR-28-38
|
P.I
|
Feb. 2009 –
Nov. 2012
|
completed
in Dec 2012
|
|
3
|
Conformational properties and
vibrational assignments of 2-methoxy-resorcinol and
4,6-dihaloresorcinols: Experimental and ab initio
study, 143,400.00 SAR, Funded by KFUPM,
Project # IN090040
|
Co-I
|
Sep. 2010 -
March 2012
|
completed
in April 2012
|
|
4
|
Development of thermally stable smart fluids for
acid diversion in well stimulation of carbonate
reservoir, 1,840,000.00 SAR, Funded
by KACST, Project # NSTIP 10-OIL1378-04
|
Co-I
|
Sep. 2012 -
Aug 2014
|
completed
in Feb 2015
|
|
5
|
Specialty diallylammonium salts-derived
pH-responsive polymers for their use in aqueous
two-phase systems and as corrosion inhibitors and
antiscalants,
1,271,000.00 SAR, Funded by KACST, Project # NSTIP 11-ADV2132-04
|
Co-I
|
Sep. 2012 -
Aug 2014
|
completed
in Sep 2014
|
|
6
|
The discovery of GGTase-1
inhibitors, potential anti-cancer drug targets,
1,135,500.00 SAR,
Funded
by KACST, Project # NSTIP 11-BIO2138-04
|
P.I
|
Sep. 2012 -
Aug 2014
|
completed
in Feb 2015
|
|
7
|
Synthesis of mafaicheenamine A
and two tyrosine derivatives, naturally occurring
antitumor agents, 109,780.00 SAR, Funded by
KFUPM, Project # SB131009
|
P.I
|
June. 2014 -
Nov 2015
|
completed
in Dec 2015
|
|
8
|
Synthesis of functionalized
polythiophenes to develop organic semiconductors,
1,254,200.00 SAR, Funded by KACST, Project #
AR-34-36
|
Co-I
|
Apr. 2014 -
Mar 2016
|
completed
in Apr 2016
|
|
9
|
Stereoinversion of
enantiopure secondary alcohols using a single
enzymatic approach, 300,000.00 SAR,
Funded by KFUPM
|
Co-I
|
April
2016 - Oct 2017
|
completed
in Oct 2017
|
|
10
|
Development of enantioselective synthetic methods
with primary amino acid-based organic catalysts,
1,108,000.00 SAR, Funded by KFUPM, Project #
NUS15103
|
P.I
|
May 2017 - April 2020
|
completed
in April 2020
|
|
11 |
Development of viscoelastic surfactant (VES)-based
acids as diverting acid fluids for well stimulation,
1,283,006.00 SAR,
Funded by Saudi Aramco |
P.I |
Dec. 2017 – Aug. 2020 |
completed
in Sep 2020 |
|
12 |
Synthesis of polymers for hydraulic fracturing at
high temperature applications in Saudi Arabia,
1,010,000.00 SAR, Funded by Saudi Aramco,
Project # CHEM-2422 |
Co-I |
Dec. 2017 – Aug. 2020 |
completed
in Sep 2020 |
|
13 |
Biology-oriented drug synthesis and diversified
bioactivities of fluoroquinolones and triazine
derivatives, 109863.00 SAR,
Funded
by KFUPM, Project # SB191017 |
P.I
|
Apr. 2020-Oct. 2022
|
completed
in Oct 2022
|
|
14
|
The design of terbium-based chemosensors for the
selective detection of zinc ions, 300000.00 SAR,
Funded
by KFUPM, Project # DF181029
|
P.I
|
April 2019 - April 2022
|
completed
in Apr 2023
|
|
15
|
Transition metal-mediated asymmetric catalysis
enabled by natural amino acid derived chiral
ligands, 180,000.00 SAR, Funded by Ministry
of Education, Saudi Arabia
|
P.I
|
Jan. 2020-Dec.2022
|
completed
in Dec 2022
|
|
16 |
Lab Level Scale-up Synthesis of Piperazine and
Morpholine-based
Viscoelastic Surfactants (VES) as Diverting Acid Fluids
for Well Stimulation, 763,561.00 SAR,
Funded by Saudi Aramco, Project #
CRAC2311 |
P.I |
Sep. 2022-Aug. 2024 |
In progress |
P.I = Principal Investigator; Co-I =
Co-Investigator
|
| All rights are reserved. KFUPM/Chemistry Department |
|