Course Description
Effects of ionizing radiation on living cells and organisms,
including physical, chemical, and physiological bases of radiation cytotoxicity,
mutagenesis, and carcinogenesis.
Main Textbook
* Radiobiology for the Radiologist. Eric J. Hall
and Amato J. Giaccia. 6th
edition, 2006, Lippincott Williams & Wilkins.
References
|
Session |
Topic |
|
1. |
Physics and Chemistry of Radiation Absorption |
|
2. |
DNA Strand Breaks and Chromosomal Aberrations |
|
3. |
Cell Survival Curves |
|
4. |
Radiosensitivity and Cell Cycle |
|
5. |
Repair of Radiation Damage |
|
6. |
Dose-Rate Effect |
|
7. |
Oxygen Effect and Reoxygenation |
|
8. |
Linear Energy Transfer and Relative Biological Effectiveness |
|
9. |
Acute Effects and Total-Body Irradiation |
|
10. |
Radioprotectors, Radiosensitizers, and Bioreductive Drugs |
|
11. |
Radiation Carcinogenesis |
|
12. |
Hereditary Effects of Radiation |
|
13. |
Effects of Radiation on Embryo and Fetus |
|
14. |
Radiation Cataractogenesis |
|
15. |
Doses and Risks in Diagnostic Radiology and Nuclear Medicine |
|
16. |
Radiation Protection |
|
17. |
Cancer Biology |
|
18. |
Oncogenes |
|
19. |
Tumor-Suppressor Genes |
|
20. |
Mitotic Death and Apoptosis |
|
21. |
Dose-Response Relationships for Normal Tissues |
|
22. |
Clinical Response of Normal Tissues |
|
23. |
Cell, Tissue, and Tumor Kinetics |
|
24. |
Time, Dose, and Fractionation in Radiotherapy |
|
25. |
Calculating Effective Doses in Radiotherapy |
|
26. |
Alternative Radiation Modalities |
|
27. |
Chemotherapeutic Agents |
|
28. |
Hyperthermia |
