 |
 |
|
|
Dr. Abdulhafez Selim January, 2008
Personal Information Name: Abdulhafez Selim, MD, PhD E-Mail: aselim@kfupm.edu.sa Work Phone: +966-3-860-7316 (KSA) Fax: +966-3-860-2293 Education and Certificates2004 PhD, Anatomy, Cell Biology and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, USA. 2000 Education Commission for Foreign Medical Graduates, ECFMG, USA 1999 Clinical Skills Assessment (CSA), USA. 1998 United States Medical License Examinations USMLE Steps 1 and 2, USA 1996 Medical License, unrestricted license to practice medicine, Egypt. 1995 Medical Degree, Ain Shams University School of Medicine, Egypt.
Work experience September 2006- present Assistant Professor, Cell Biology, Molecular Biology and DNA Technology at Biotechnology Excellency Research Center and Medical Biophysics Program, King Fahd University for Petroleum and Minerals (KFUPM), Saudi Arabia.
October 2003- August 2006 Postdoctoral Fellow, Molecular Endocrinology, Endocrine Unit, Mass General Hospital, Harvard Medical School, Boston, USA.
June 2000- September 2003: Research Assistant, Anatomy, Cell Biology and Molecular Biology Department, Temple University School of Medicine, Philadelphia, PA, USA.
July 1999-May 2000: Research Fellow, Tissue Engineering and Molecular Engineering Center, Drexel University, Philadelphia, PA, USA.
June 1998-June 1999: Resident, Clinical Pathology Department, Ain Shams University School of Medicine, Egypt.
May 1997- May 1998: General Practitioner, Egyptian Drilling Company Hospitals, Egypt.
April 1996-April 1997: General Practitioner, government suburban clinics, Ministry of Health, Egypt.
March 1995-March 1996: Resident, Transitional year, Ain Shams University School of Medicine, Ain Shams University Hospitals, Egypt. Industrial Experience
2005-2006: Consultant, Alpine Pharmaceuticals, Boston, USA Role: · Prepared Clinical database for Universal Electromagnetic Pulsed Device (UEMPD).
· Designed a randomized, double blind, placebo controlled, parallel study group to assess the safety and efficacy of pulsed electromagnetic therapy in treatment of essential hypertension.
· Prepared FDA application for UEMPD.
Publications Journal Papers 1- Idriss N, Selim A, Khachemoune A. Dusky plaque on the knee. J Fam Pract. 2008 Feb;57(2):97-9.
2- Selim A, Julian L. Castaneda, Steven Popoff and Fayez Safadi The Role of Osteoactivin-Derived Peptides in Osteoblast Development. Med Sci Monit. 2007 Dec;13(12):BR259-270. [Full Article]
3- Heba Selim, Selim A, Amor Khachemoune and Sallah Abdulfattah. Use of sclerosing agent in the management of oral and perioral hemangiomas: review and case reports. Med Sci Monit. 2007 Sep;13(9):CS114-119. [Full Article]
4- Sarabi K, Selim A, Khachemoune A .A young girl with blisters on her forehead. J Fam Pract. 2007 Jul;56(7):551-3. [Full Article] 5- Sarabi K, Selim A, Khachemoune A. Sporadic and syndromic keratoacanthomas: diagnosis and management. Dermatol Nurs. 2007 Apr;19(2):166-70.
6- El-Ghandour A, Selim A, Khachemoune A. Bilateral lesions on the legs. J Fam Pract. 2007 Jan;56(1):37-9.
7- Selim A, Ehrsam E, Atassi MB, Khachemoune A. Scar sarcoidosis: a case report and brief review. Cutis. 2006 Dec;78(6):418-22.
8- Banerjee S, Selim A, Suliman G, Geller AI, Juppner H, Bringhurst FR, Divieti P. Synthesis and characterization of novel biotinylated carboxyl-terminal parathyroid hormone peptides that specifically crosslink to the CPTH-receptor. Peptides. 2006 Dec;27(12):3352-62. [Full Article]
9- Selim A, M. Mahon, H. Jueppner, F. R. Bringhurst and P. Divieti. Role of Voltage Dependent Calcium Channels in Carboxyl-Terminal Parathyroid Hormone Receptor Signaling. Am J Physiol Cell Physiol. 2006 Jul;291(1):C114-21. [Full Article]
10- Selim A, Khachemoune A, Lockshin NA. Angiosarcoma: a case report and review of the literature. Cutis. 2005 Nov;76(5):313-7.
11- Litvin J, Selim A, Montgomery MO, Lehmann K, Rico MC, Devlin H, Bednarik DP, Safadi FF. Expression and function of periostin-isoforms in bone. J Cell Biochem. 2004 Aug 1;92(5):1044-61. [Full Article]
13- Safadi FF, Xu J, Smock SL, Kanaan RA, Selim A, Odgren PR, Marks SC Jr, Owen TA, Popoff SN. Expression of connective tissue growth factor in bone: its role in osteoblast proliferation and differentiation in vitro and bone formation in vivo. J Cell Physiol. 2003 Jul;196(1):51-62. [Full Article]
Manuscripts submitted or in press1- Heba Selim, Shagufta Shaheen, Khalid Salah and Selim A. “Melanotic neuroectodermal tumor of infancy: clinical and pathological review and case report. (2008) (In Press, J of Ped Surg).
2-
Selim A,
Shagufta Shahin , Noraman Lockshin and Amor Khachemoune “Cutaneous metastasis of Uterine Adenocarcinoma: a case report and brief
3- “The Effects of Modulating Osteoactivin Function on Osteoblast Differentiation”. A. Selim, S. M. Abdelmagid, S. L. Smock, T. A. Owen, S. N. Popoff, F. F. Safadi. (Submitted to Med Sci Mont) 4- “A Novel Mechanism For Chondrocyte Regulation Of Transformin Growth Factorβ Biological Availability During Chondrocyte Hypertrophy” Aja M. Montgomery, Victoria L. Scheinfeld, Brendan N. Dragann, Brittany M. Mentzer, Scott K. Roger, Elizabeth Jennings, Patrisia M. Mattioli, Abdulhafez Selim and Marina D’Angelo Submitted to JBC 5- “Parallel Microfluidic Cytometer for Rare-Cell Screening”. Abdulhafez Selim , Brian McKain , John T Potts , Richard Bringhurst , Danial Enlrich. (Submitted to Nature Techniques)
6- “The Receptor for Carboxyl-Terminal Parathyroid Hormone Regulates Osteocyte Cytoskeleton through Calcium Influx Dependent Mechanisms” A. Selim, M. Juppner, F. R. Bringhurst and P. Divieti. (In preparation)
7- “Receptors for Carboxyl-PTH on Pheochromocytoma Cells Trigger Calcium Influx and Regulate Secretion”. Selim A,, Jueppner H, Potts J, Bringhurst R and Divieti P. (In preparation).
8- "Non-covalent Interaction of MMP13 and LTBP1 in a Unique TGFβ Large Latent Complex Produced by Hypertrophic Chondrocytes" B. N. Dragann, V. L. Scheinfeld, S. M. Routson, B. M. Mentzer, P. M. Mattioli, Selim A, D. M. Appelt, M. D'Angelo. (In preparation)
9- “Assessment of the level of sICAM-1 in chronic hepatitis patients and its correlation with the serum concentration of transaminases and other liver function parameters”. Sahar Ghoname, Abdulhafez Selim and Osama Raslan. (In preparation)
10- “Structural and functional analysis of Osteoactivin protein using bioinformatic tools”. Abdulhafez Selim. (In preparation).
11- “Use of amniotic stem cells for common bile duct repair” Abdulhafez Selim and Alla Ismail. (In preparation).
Conference Papers 1- Brendan N. Dragann 1, Stephanie M. Routson 1, Abdulhafez Selim 2 and Marina D’Angelo 1. "Activation of Transforming Growtg Factor b (TGFb) by interaction of Matrix Metalloproteinase 13 (MMP-13) with the large latent complex". April 2008, Experimental Biology, San Diego, CA, USA. 1- Philadelphia College of Osteopathic Medicine, Center for Chronic Disorders of Aging, Philadelphia, PA 19131, 2- Biotechnology Center, College of Science, KFUPM, Dharan, Saudi Arabia 31261.
2- B. N. Dragann*1, V. L. Scheinfeld*1, S. M. Routson*1, B. M. Mentzer*1, P. M. Mattioli*1, A. H. Selim2, D. M. Appelt*1, M. D'Angelo1. "Non-covalent Interaction of MMP13 and LTBP1 in a Unique TGFβ Large Latent Complex Produced by Hypertrophic Chondrocytes" September 2007, American Society for Bone and Mineral Research (ASBMR), 29th annual meeting, USA. 1Center for Chronic Disorders of Aging, PCOM, Philadelphia, PA, USA, 2Department of Biology and Physics, KFUPM, Dhahran, Saudi Arabia.
3- A. A. Selim*1, K. Mezghani*2, A. Abou-Samra3, D. Al-Tamimi*4. "Percutaneous Injection of Allantoin Accelerates Fracture Repair” September 2007, American Society for Bone and Mineral Research (ASBMR), 29th annual meeting, USA. 1Biotechnology Center, KFUPM, Dhahran, Saudi Arabia, 2Mechanical Engineering, KFUPM, Dhahran, Saudi Arabia, 3Wayne State University School of Medicine, Detroit, MI, USA, 4Pathology Department, College of Medicine, King Faisal University, Al-Khobar, Saudi Arabia.
4- Brendan N. Dragann, Patrisia M. Mattioli, *Abdulhafez Selim, Brittany M. Mentzer, Victoria L. Scheinfeld, Denah Appelt and Marina D’Angelo. “Hypertrophic Chondrocytes Produce a Novel TGFb Large Latent Complex that contains MMP13 in Non-covalent Association”. March 2007, Society of Developmental Biology Meeting, Washington DC, USA. Center for Chronic Disorders of Aging, Philadelphia College of Osteopathic Medicine and * Biomedical Physics Department, KFUPM, Saudi Arabia
5- Abdulhafez Selim 1, Brian McKain 2, John T Potts 3, Richard Bringhurst 3, Danial Enlrich2. “Parallel Microfluidic Cytometer for Rare-Cell Screening”. March 2007, Third Saudi Science Conference, Riyadh, Saudi Arabia. 1- KFUPM , Dhahran, Saudi Arabia, 2-MIT, Boston, USA, 3- Harvard Medical School, Boston, USA.
6- Selim A, Banarjee S, Jueppner H, Potts J, Bringhurst R and Divieti P. “Receptors for Carboxyl-PTH on Pheochromocytoma Cells Trigger Calcium Influx and Regulate Secretion”. August 2006, Mass General Hospital (MGH) Research Fellows Poster Celebration 2006, USA. Endocrine Unit, Mass General Hospital, Harvard Medical School, Boston, USA.
7- A. Selim, S. Banerjee, H. Jüppner, J. Potts, R. Bringhurst, P. Divieti. September 2006, “Receptors for Carboxyl-PTH on Pheochromocytoma Cells Trigger Calcium Influx and Regulate Secretion” American Society for Bone and Mineral Research (ASBMR), 28th annual meeting, Philadelphia, PA, USA. Endocrine Unit, Mass General Hospital, Harvard Medical School, Boston, USA.
8- S. Banerjee, A. Selim, G. Suliman, H. Jüppner, F. Bringhurst, P. Divieti. “Initial Proteomic Analysis of the Partially Purified Carboxyl-PTH Receptor(s) in Bone Cells” September 2006, American Society for Bone and Mineral Research (ASBMR), 28th annual meeting, Philadelphia, PA, USA. Endocrine Unit, Mass General Hospital, Harvard Medical School, Boston, USA.
9- A. Selim, M. Juppner, F. R. Bringhurst and P. Divieti. “The Receptor for Carboxyl-Terminal Parathyroid Hormone Regulates Osteocyte Cytoskeleton through Calcium Influx Dependent Mechanisms” September 2005, American Society for Bone and Mineral Research (ASBMR), 27th annual meeting, Nashville, TN, USA. Endocrine Unit, Mass General Hospital, Harvard Medical School, Boston, USA.
10- A. Selim1, B. McKenna*2, S. El-Difrawy*2, H. Juppner1, P. Divieti1, D. Ehrlich*2, R. Bringhurst1. “Development of a Novel Cell-Scanning System (Cell Track) for Expression Cloning of The Carboxyl-Terminal Parathyroid Hormone Receptor (CPTHR)” September 2005, American Society for Bone and Mineral Research (ASBMR), 27th annual meeting, Nashville, TN, USA. 1Endocrine Unit, MGH, Boston, MA, USA, 2White Head Institute, MIT, Boston, MA, USA.
11- A. Selim*, Patrisia M. Mattioli, Victoria L. Scheinfeld, and Marina D’Angelo. “A Novel Large Latent Complex of TGF-b2 is Produced by Hypertrophic Chondrocytes. A Novel Large “Latent Complex of TGF-b2 is Produced by Hypertrophic Chondrocytes”. September 2005, American Society for Bone and Mineral Research (ASBMR), 27th annual meeting, Nashville, TN, USA. *1Endocrine Unit, MGH, Boston, MA, USA. Department of Anatomy, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania 19131
12- A. Selim, M. Mahon, H. Juppner, F. R. Bringhurst and P. Divieti “Role of Voltage Dependent Calcium Channels in Carboxyl-Terminal Parathyroid Hormone Receptor Signaling” September 2004, American Society for Bone and Mineral Research (ASBMR), 26th annual meeting, Seattle, Washington, USA. Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 13- J. Litvin*, A. Selim*, M. O. Montgomery*, M. C. Rico*, K. Lehmann*, F. F. Safadi. September 2003, “The Role of Splice-Variants of Periostin in Bone Development and Disease” American Society for Bone and Mineral Research (ASBMR), 25th annual meeting, Minneapolis, MN, USA. Anatomy and Cell Biology Department, Temple Medical School, Philadelphia, PA, USA.
14- Selim A*1, J. L. Castaneda*1, T. A. Owen2, S. N. Popoff1, F. F. Safadi1. “Osteoactivin-Derived Peptides Induce Osteoblast Differentiation in MC3T3-E1 Cells” September 2003, American Society for Bone and Mineral Research (ASBMR), 25th annual meeting, Minneapolis, MN, USA. 1Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA, 2Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, CT, USA.
15- A. Selim*1, S. M. Abdelmagid*1, S. L. Smock*2, T. A. Owen2, S. N. Popoff1, F. F. Safadi1. “The Effects of Modulating Osteoactivin Function on Osteoblast Differentiation”. September 2002, American Society for Bone and Mineral Research (ASBMR), 24th annual meeting, San Antonio, TX, USA. 1Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA, 2Cardiovascular and Metabolic Diseases, Pfizer Global R&D, Groton, CT, USA. 16- S. N. Popoff*1, F. F. Safadi*1, M. D'Angelo*1, A. H. Selim1, V. Zakhaleva1, S. L. Smock2, T. A. Castleberry*2, B. Lu2, S. C. Marks*3, T. A. Owen*2. “Connective Tissue Growth Factor (CTGF) Promotes Osteoblast Differentiation and Stimulates Bone Formation” September 2001, American Society for Bone and Mineral Research (ASBMR), 23rd annual meeting, USA. 1Anatomy and Cell Biology, Temple Univ. School of Medicine, Philadelphia, PA, USA, 2Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, CT, USA, 3Cell Biology, Univ. of Massachusetts Medical School, Worcester, MA, USA.
17- F. F. Safadi*1, A. H. Selim1, V. Zakhaleva1, R. Kanaan1, A. Ravindra1, M. D'Angelo*1, S. L. Smock2, T. A. Owen*2, S. N. Popoff*1. “Osteoactivin: A Novel Factor That Regulates Osteoblast Development and Function” September 2001, American Society for Bone and Mineral Research (ASBMR), 23rd annual meeting, USA. 1Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA, 2Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, CT, USA.
ThesisSeptember 2003 PhD Thesis: “The Role of Osteoactivin and Osteoactivin-Derived Peptides in Osteoblast Differentiation and Bone Formation”. [Link] Books2007 Selim A and Paola D, “Osteocytes Biology and Its Clinical Implications” (In preparation).
Monographs2007 Abdulhafez Selim and Khachemoune A, Vitiligo, BMJ, UK (In Press). 2007 Abdulhafez Selim, Vitamin B3 deficiency. BMJ, UK (Accepted).
Oral Presentations. 2007 Selim A, “Use of Bioinformatic Analysis for Drug Design” Physics Department Seminar, KFUPM, Dhahran, Saudi Arabia
2007 Selim A “Parallel Micro fluidic Cytometer for Rare-Cell Screening” Third Saudi Science Meeting, Riyadh, Saudi Arabia
2007 Selim A “Molecular Biology of Bone Healing ” Chemistry Department Seminar, KFUPM, Dhahran, Saudi Arabia
2006 Selim A, “a mis-sense mutation in transmembrane domain of the human calcium receptor converts a negative allosteric modulator into a positive allosteric modulator”. Endocrine Unit, Cell Signaling Journal Club, MGH, Boston, USA.
2006 Selim A, “Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling” Endocrine Unit, Developmental Biology Journal Club, MGH Boston, USA.
2005 Selim A, “A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells”. Endocrine Unit, Developmental Biology Journal Club, MGH. Boston, USA
2005 Selim A, “The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate”. Endocrine Unit, Developmental Biology Journal Club, MGH.
2005 Selim A, Cell Track Scanning System, Endocrine Unit Seminar, MGH. Boston, USA
2004 Selim A, “CPTH receptor: expression cloning and function”, Endocrine Unit Seminar, MGH.
2003 Selim A, “ Oral Gene therapy for peanut allergy”, student seminar, Temple University School of Medicine, Philadelphia, USA.
2002 Selim A,” OCIL is a novel factor secreted by osteoblast and inhibits osteoclast differentiation”, student seminar, Temple University School of Medicine. Philadelphia, USA.
2002 Selim A, “role of TGF-B receptor in circadian rhythm regulation” student seminar, Temple University School of Medicine.
2001 Selim A, “Role of Osteoactivin in Osteoblast Differentiation” Graduate Student Research Day, Temple University School of Medicine. Philadelphia, USA.
2001 Selim A, “Delivery of a Cyclic Adenosine Monophosphate Response Element-Binding Protein (CREB) Mutant to Seminefrous Tubules Results in Impaired Spermatogenesis”, student seminar, Temple University School of Medicine. Philadelphia, USA.
2000 Selim A, “Phosphorylation of Transcription Factor CREB in Rat Spinal Cord after Formalin Induced Hyperalgesia: Regulation to c-fos Induction”, student seminar, Temple University School of Medicine. Philadelphia, USA.
Selim A, “Lack of Regulation in the Heart Forming Region of Avian Embryos”, student seminar, Temple University School of Medicine. Philadelphia, USA.
1993 Selim A, “Risk Factors in Cervical Cancer.” Obstetrics and Gynecology Department, student seminar, Ain Shams University School of Medicine, Cairo, Egypt. . 1993 Selim A, “Aspirin Abuse.” Public Health Department, student seminar, Ain Shams University School of Medicine. Cairo, Egypt.
Work Shops Presented
2007 Selim A. “Use of Bioinformatic Tools for Proteins and Peptides Analysis”, Philadelphia College of Osteopathic Medicine PCOM, Philadelphia, PA, USA.
Grant Awards
v September 2007 developing novel database mining for biological and medical applications, KACST, Co-investigator, Saudi Arabia.
v March 2007 Use of Functional Networks to Predict Protein Relative Solvent Accessibility, Co-investigator, Junior Faculty Grant, KFUPM, Saudi Arabia.
v March 2008 Treatment of osteoarthritis model using MMP13-derived peptide. Principal Investigator, SABIC Fast track grant, Saudi Arabia. Membership In Professional Societies 2000- Present American Society of Bone and Mineral Research (ASBMR), Washington DC, USA. Awards 2007 Travel Grant Award, ASBMR 29th Annual Meeting, Hawaii, USA
2007 Oral Presentation Award, Third Saudi Science Meeting, Riyadh, Saudi Arabia
2005 Partners In Excellency Award, MGH, Harvard Medical School. Boston, MA, USA.
2002 Best Poster Presentation, Graduate Student Research Day, Temple University School of Medicine. Philadelphia, PA, USA.
2002 Best Graduate Student Presentation, Graduate Student Research Day, Temple University School of Medicine, Philadelphia, PA, USA.
2002 Oral Presentation Award, Bone and Mineral Research Conference, annual meeting, San Antonio, Texas. USA
2001 Best Poster Presentation, Graduate Student Research Day, Temple University School of Medicine, Philadelphia, PA, USA.
2001 Best Graduate Student Presentation, Cell Biology Department Graduate Student Research Day, ranked first among 9 students. Temple University School of Medicine. Philadelphia, PA, USA.
Temple University Fellowship, ranked first among 28 applicants. Philadelphia, USA.
Hobbies Football and Reading.
References References available upon request
|