Syllabus
Home Teaching Research Medical Physics

 

 

Course Title

:

Radiobiology

Course Code

:

MEPH 510

Credit Hours

:

2

Prerequisite

:

Graduate Standing

     

Course Description

Effects of ionizing radiation on living cells and organisms, including physical, chemical, and physiological bases of radiation cytotoxicity, mutagenesis, and carcinogenesis.

 

Main Textbook

* Radiobiology for the Radiologist.  Eric J. Hall and Amato J. Giaccia. 6th edition, 2006, Lippincott Williams & Wilkins.

 

References                    

* Applied Radiobiology and Bioeffect Planning.  Wigg [RC271.R3 W54 2001]
* An Introduction to Radiobiology.  Nias [R895.N53 2000]

 

Teaching Tools

* Computer presentations

* Blackboard

* Transparencies

* Internet online courses

* Group discussions

 

Assessment

Activity Weight
Homework 10%
Exam #1 30%
Exam #2 30%
Final Exam 30%

 

Grading

Grade

Mark

A+ ≥89
A 82-88
B+ 75-81
B 68-74
C+ 61-67
C 54-60
D+ 47-53
D 40-46
F <40

 

Course Content

Session

Topic

1.

Physics and Chemistry of Radiation Absorption

2.

DNA Strand Breaks and Chromosomal Aberrations

3.

Cell Survival Curves

4.

Radiosensitivity and Cell Cycle

5.

Repair of Radiation Damage

6.

Dose-Rate Effect

7.

Oxygen Effect and Reoxygenation

8.

Linear Energy Transfer and Relative Biological Effectiveness

9.

Acute Effects and Total-Body Irradiation

10.

Radioprotectors, Radiosensitizers, and Bioreductive Drugs

11.

Radiation Carcinogenesis

12.

Hereditary Effects of Radiation

13.

Effects of Radiation on Embryo and Fetus

14.

Radiation Cataractogenesis

15.

Doses and Risks in Diagnostic Radiology and Nuclear Medicine

16.

Radiation Protection

17.

Cancer Biology

18.

Oncogenes

19.

Tumor-Suppressor Genes

20.

Mitotic Death and Apoptosis

21.

Dose-Response Relationships for Normal Tissues

22.

Clinical Response of Normal Tissues

23.

Cell, Tissue, and Tumor Kinetics

24.

Time, Dose, and Fractionation in Radiotherapy

25.

Calculating Effective Doses in Radiotherapy

26.

Alternative Radiation Modalities

27.

Chemotherapeutic Agents

28.

Hyperthermia