Computational Aspects of percutaneous Drug Absorption

E.H. Twizell*

The topical application of a finite dose of drug (ointment) is common practice. Simple models treat the absorption process as a linear diffusion problem but more advanced models, such as the dual absorption model which will be considered in the talk, treat the absorption as a non-linear diffusion process. A linear repeated-dose model will be presented and simultaneous metabolism will also be discussed. Finite-difference methods will be used to obtain concentration profiles.

*In collaboration with A.A. Al Ali, A.B. Gumel and K. Kubota