Computational Aspects of percutaneous Drug Absorption


E.H. Twizell*



The topical application of a finite dose of drug (ointment) is common practice.  Simple models treat the absorption process as a linear diffusion problem but more advanced models, such as the dual absorption model which will be considered in the talk, treat the absorption as a non-linear diffusion process.  A linear repeated-dose model will be presented and simultaneous metabolism will also be discussed.  Finite-difference methods will be used to obtain concentration profiles.


*In collaboration with A.A. Al Ali, A.B. Gumel and K. Kubota