CURRICULUM VITAE - DR. A. A. ISAB
Dr. Anvarhusein A. Isab
22nd April 1950.
Permanent Address: Motataiwad,
Address: KFUPM #
1964 Dhahran 31261, Saudi Arabia
Tel:(009663) 860-5735 (Res.)
860-2645(Off) FAX: 860-4277
Joined KFUPM: Asst. Prof.: Sept. 1981 to Apr. 1984
1984 to Dec 1996
: Jan 1997
Ph.D. 1978 Birkbeck College (Univ. of London, UK) Bio-Inorganic Chemistry
NMR Studies of Biologically Interesting Gold . Complexes (May 1978, Univ.
Areas of Specialization:
1. Gold Biochemistry (Anti-arthritic Drugs)
The main research area emphasize the biological and
inorganic chemistry of gold(I)-thiolate complexes which are active as
antiarthritic agents. The ligand exchange reactions are being investigated by
using NMR spectroscopy.
Imidazolidine-2 thione/Methionine/Selenomethionie and their derivatives
are used as model ligands to synthesize various heavy metal complexes.
Captopril (A High Blood Pressure Drug)
Captopril which has been used as a high blood pressure drug forms a
crystalline complex with gold(I), which is first time in the history of gold(I)-thiolate
complex is being crystalline. NMR is used to study the interaction of captopril
with other heavy metal ions.
Impact of Cyanide ion on Smokers who are treated with Gold Drugs
We are currently studying the reaction
mechanism of cyanide ion with gold(I) drugs. Smokers on gold(I) therapy is found
to have more toxic effects than nonsmokers. NMR is used to study the exchange
Red Blood Cells/ Serum Albumin
The interaction of heavy metal ions with red blood cells as well as with
serum albumin being investigated by NMR spectroscopy.
and R3PAuSCN new complexes are being synthesized which may have
Selenocyanate and thiocyanate interactions
Recently my Ph.D. student is working on the interaction of Selenocyanate
and thiocyanate with Gold (I) drugs to understand the disproportionation
reaction of the type CNSe-Au-thiols.
Solid state NMR studies Cd (II)-thione/selone complexes
We have recently started synthesizing various Imidazolidine-2-thione and
its derivatives complexes with Cd(II) and study them solution as well as in
solid state in collaboration with Dr. M. I. M. Wazeer.
Ag13C15N complexes with thiones/selones
complexes are being synthesized with thiones/selones and study them with 109Ag
CHEM 710 Ph.D. Thesis
CHEM 610 MS Thesis
CHEM 522 Organometallic Chemistry I
CHEM 521 Advance Coordination Chemistry
CHEM 463 Environmental Chemistry
CHEM 412 Chem. Senior Project II
CHEM 411 and CHEM 471 Chem. Senior Project I
CHEM 409 Chem. Seminar
CHEM 331 Inorganic Chemistry
CHEM 315 Introduction to Literature
CHEM 306 Inorganic Chem. II (Lec./Lab)
CHEM 161 Introduction to General Chemistry
CHEM 111 Basics of Environmental Chemistry
CHEM 102 General Chemistry II (LLF)
101 General Chemistry I
of CHEM 102 course:
102: Coordination of course during 1983 to 1986 Preparing Lect/Lab Schedule,
Reservation of Auditoriums, Coordinating all Major and Final exams for
800 to 1000 students, Prepare a final report for the Chairman.
Fall ’89 to Spring ’02 (13 years of coordination of Freshmen CHEM 101
and CHEM 102 Labs). I was involved in the development of the Freshmen
Responsibilities: As a Freshman Lab Coordinator:
(a) I was responsible for the CHEM 101/102 lab manuals to be printed by KFUPM press (total about 1000-1200 per year).
(b) To supervise one chemist + two lab technicians.
(c) To order chemicals and glassware for various experiments.
(d) To substitute for any faculty members who is absent or cannot take any freshman labs (emergency).
During summer session, I helped in arranging labs assignments to different technicians so that labs run smoothly during summer.
Inorganic Division Supervisor:
Manuals CHEM 161
Revised CHEM 161 Lab manual while teaching the course. Printed 110 copies from
1987-1989 each year.
CHEM 411/CHEM 412
have supervised several senior research projects.
1. Holder of British Council Award
Sept. '74 to June '78.
2. Alberta Heritage
Foundation for Medical Research Fellowship (Edmonton, Alberta, Canada) Sept. '80
to Aug. '81.
3. UWM NIEHS (Milwaukee WI USA) Marine and
Fresh water Biomedical Core Center
Grant to carry out research on Lobster's Metallothionine June-Aug., 1989.
4. The Best
Research Award 1995-96.
The Best Research Award 2001-02.
April '74 to May 78, working as a Demonstrator for undergrad. students
whilst working as a graduate student for Ph.D.
Aug.'77 to Feb.'78, with ICI (UK) Ltd. on development and analysis of
formulated and bulk drugs by NMR and other physical techniques.
Postdoctoral Research Fellow at the Chem. Dept. with Prof. D. L.
Rabenstein (Univ. of Alberta, Canada) Nov.
78 to Aug. 81.
4. Sept. '81 to date:
Teaching various Chemistry courses at the
Member of the American Chemical Society since 1979.
Member of the Saudi Arabian Intl. Chapters of the American Chemical
Society since 1988.
Visiting Prof. to the Chem. Dept., Univ. of Alberta during June '83 to
Aug. '83 and June '84 to Aug. '84.
Visiting Prof. to the Chem. Dept., Univ. of Wisconsin, Milwaukee during
June '89 to Aug. '89 and July '94 to Sept. '94.
Worked with Prof. C. F. Shaw III at the Chem. Dept., Univ. of Wisconsin,
Milwaukee, USA, during July 86 to Aug. 87. Published seven papers in the
well-reputed journals like J. Am. Chem. Soc., Inorg. Chem., Biochem. Pharm. etc.
Two more papers are under preparations.
Second Sabbatical Leave Aug. 97-Aug. 98. The title of the proposal,
"Studies of Nucleotide and DNA Binding to Metallo-Anticancer Drugs".
Host Scientist: Prof. L. G. Marzilli, Chemistry Department, Emory University,
Smith Kline Beecham Pharm. (USA) into their Gold(I) based anti-arthritic
drug programs (see publication nos. 17, 40, 43). Bristol Myers Squibb Pharm.
Research Inst. for Medical Res.(USA) provides captopril (A high blood pressure
drug) for my research. I collaborate my research with several faculty members
here at KFUPM (see several of my publications). I also have international
collaborators e.g. Prof. C. F. Shaw III (USA); Prof. P. J. Sadler (UK); Prof. J.
D. Hoeschele (USA); Prof. G. Stocco (Italy) etc.
Research Projects at KFUPM:
"Interaction of Metal Ions
with Biologically Active Thiol Molecules Studies of NMR Spectroscopy".
Duration: Apr.'82 to Mar.'84 (CY/METALION/54). Investigator: DR. A. A. ISAB
(Number of papers generated: six)
"NMR Studies of
Imidazolidine-2-thione and its derivatives"
Duration: Jan. '85 to Dec.'88 (CY/NMRSTUDY/92).
Investigator: DR. A. A. ISAB
(Number of papers generated: seven)
"Exchange Reactions of
Bis(Thiomalato)-Gold(I) Complex with Thiols and other Biologically Important
Duration: Jan.'91 to Dec.'93 (CY/DRUG/124).
Investigator: DR. A. A. ISAB
(Number of papers generated: fourteen)
and 31P NMR Studies of the interaction
of Cyanide Ion with Gold(I) Complexes"
Duration: Oct.'95 to Dec '99
Investigators: DR. A. A. ISAB (Principal Investigator) and DR. A.
Al-ARFAJ (Co-Investigator) (Number
of papers generated: ten)
and 109Ag NMR Studies of M(I)-Imidazoloidine-2-thione and
Imidazoloidine-2-selenone Complexes (Where M = Ag and Au)"
Duration: Sept.'00 to Mar '03 (CY/NMR-STUDIES/214).
Investigators: DR. A. A. ISAB (Principal Investigator), DR. A. Al-ARFAJ
(Co-Investigator) and Dr. H. Perzanowski (Co-Investigator).
(Number of papers generated : fourteen so far).
31P and 77Se NMR Studies of the Redox and Exchange
Reactions of Gold(I) Drugs with Bis(alkylthio)selenides of Biological Thiols”
Duration: Apr. '03 to Oct. '04
Investigators: DR. A. A. Isab (Principal Investigator), DR. Waqar
Chairman of the
Committee (MS degree)
and 13C NMR Studies of the Interaction
of Cyanide ion with Gold Drugs", by
Mr. Ibrahim H. Gazi (MS,
Completed June 1993). (Three papers have been published from his MS thesis;
Publication # 52, 53 and #61).
and 15N NMR Studies of Ligand Exchange
Reactions of Auranofin and the Synthesis of
Gold(I) Complexes with Phosphine Sulfides and Phosphine Selenides", by
Mr. Saeed Ahmad (MS, Completed Nov
1997). (One paper have been published from his MS thesis; Publication # 72).
Chairman of the
Committee (Ph.D. degree)
15N and 31P NMR Studies of the Scrambling Reactions and
the Redox Reactions of Some Gold(I) Complexes" by
Mr. M. N. Akhtar(ID # 920347) (Nine papers have been published). (PhD,
Degree awarded in Sept. 1996).
Characterization and NMR Studies of Some Gold (I) and Silver (I)
Complexes with Cyanides, Thiones and Selenones” by
Mr. A. Saeed
( ID # 950437) (Thirteen papers
have been published). (PhD, Degree
awarded in January, 2002).
Member of the Committee (MS degree)
"Heterocyclic thione Complexes of Group IB Metals: Models of Gold
Drugs", by M. L. Hossain.
(MS, Degree awarded in June 1988).
Member of the
Committee (Ph.D. degree)
1. "NMR Study of Nitrogen
Inversion and N-O Torsional Barriers and Anomeric Effect in Hydroxylamine
Derivatives". (PhD, Degree awarded in Oct 1997). (Ph.D.;
Mr. Hassan Azfar ID # 910596)
“Chain Transfer Agents: Characterizations and their use in
Polymerization Reactions”. (PhD, Degree awarded in Jan. 2003).(PhD;
Mr. Shafique Ahmad, ID No. 970329)